Fatal hepatitis and renal failure during treatment with nimesulide

Nimesulide-induced hepatotoxicity and fatal hepatic failure.

Non-steroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase-2 (cox-2) inhibitors are structurally heterogeneous drugs that share similar therapeutic actions and adverse effects. Hepatotoxicity, although a relatively rare adverse effect of this class of drugs, can be severe. This has led to the withdrawal of some NSAIDs from the market. Nimesulide is an NSAID, with cox-2 preference, which...

Fatal acute liver failure with hepatitis B virus infection during natalizumab treatment in multiple sclerosis

Fatal acute liver failure with hepatitis B virus infection during nataluzimab treatment in multiple sclerosis

A 28-year-old woman with multiple sclerosis (MS) presented to the emergency department (ED) at University Hospital in Newark, NJ on March 10, 2011 with epigastric abdominal pain, a low-grade fever, chills, shortness of breath, pleuritic pain, and impaired balance of 2 days’ duration. She also reported right arm numbness and dizziness, consistent with her previous symptoms of MS. She had 3 episo...

Nimesulide and acute renal failure caused by oxalate precipitation.

Sir, Acute renal failure (ARF) seen with non-steroidal anti-inflammatory drugs (NSAIDs) is mainly haemodynami-cally mediated due to inhibition of the synthesis of renal prostaglandins (PGs) w1x. Nimesulide is a new generation NSAID that differs from conventional NSAIDs in structure and pharmacological profile, claiming fewer side effects due to the specificity for the COX-2 enzyme w2x. We descr...

Nimesulide-induced acute hepatitis

Nimesulide is a non-steroidal anti-inflammatory drug with a semiselective preferential inhibition of cyclooxygenase2. We present a 57 year-old patient with jaundice and increased serum aminotransferases levels, who had been treated with nimesulide for the previous 10 days. Laboratory examinations excluded other causes of acute liver injury. Liver biopsy revealed lesions compatible with drug-ind...